P-199 Astrocytes pretreated with lysine or glutaric acid provoke neurotoxic effects in striatum and cerebral cortex from a Gcdh−/− mouse model 2014
Glutaric acidemia I (GAI) is a neurometabolic disease characterized by brain accumulation of glutaric acid (GA) and related metabolites and acute degeneration of striatal neurons through still unknown mechanisms. We investigated whether astrocytes from the Gcdh−/− mice submitted to lysine (Lys) or GA overload may...