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P-202 Routine use of a secondary ion transition to facilitate identification of glutarylcarnitine in plasma and bloodspot acylcarnitine profiling by tandem mass spectrometry 2014

Objectives: To improve the identification of glutarylcarnitine at low concentrations in routine profiling of acylcarnitines by LC-MS/MS. This is important for detecting low-excretor variants of glutaryl-CoA dedrogenase deficiency (GA-1) and in multiple acyl-CoA dehydrogenase deficiency (MADD), but can be problematic due to isobaric interferences. Method: Alongside...